Bisa Butler was born to educators in Orange, NJ, the youngest of four children. Butler earned a BFA from Howard University, where she refined her natural talents under the tutelage of lecturers such as Elizabeth Catlett, Jeff Donaldson, and Ernie Barnes. She later began to experiment with fabric as a medium and collage technique. During graduate studies at Montclair State University, where she earned her MA in 2005, she took a Fiber Arts class and had an artistic epiphany, finally realizing how to express her art by combining painting and drawing skills with sewing.
Butler worked as a high school art teacher for ten years in Newark Public Schools and for three years at Columbia High School in Maplewood, NJ. Her work has been acquired by the Art Institute of Chicago, the Museum of Fine Arts, Boston, the Nelson-Atkins Museum of Art in Kansas City, MO, the Orlando Museum of Art in Florida, the Minneapolis Institute of Art, and many other public and private collectors. In the fall of 2020, a solo exhibition of her work opened at the Art Institute of Chicago, the second stop of a traveling exhibit that began at the Katonah Museum of Art in Katonah, NY; her work was concurrently featured as part of a group show at the Toledo Museum of Art in Ohio. Butler is represented by Claire Oliver Gallery in New York.